Summary: Screening and analysis of the scientific literature for gene drive development in non-insect targets up to 31 December 2023,1 showed: (i) There are 46 current or proposed non-insect targets; (ii) Proposals span a wide range of species and taxonomic groups: from mammals and fish to snails, arachnids, fungi and plants; (iii) In the vast majority of cases the aim is to suppress or eradicate the target; (iv) Compared to gene drive systems in insects, the systems in other taxonomic groups are further away from releases into the environment; (v) A significant amount of research has focused on developing gene drives in mice, so far with limited success, though efforts are ongoing; (vi) Development of gene drives in mice is seen by many as a pathway to applying the technology in other mammals; and (vii) There appear to be significant obstacles in applying homing CRISPR gene drive technology in new species and taxonomic groups.